Best cleaner for dog urine on a mattress

Every mattress cleaner we checked for dog urine

We checked whether each maker names mattresses on its own page, because most pet cleaners list carpets and floors only.

Every mattress cleaner we checked for dog urine

Product	Type	Mattress on the maker page	How long it sits	Oils cats react to	Cost per oz (ready to use)	Price
Rocco & Roxie Stain & Odor Eliminator, 32 fl oz1	Bacteria and enzymes	Names mattresses	1 hour or more; up to days for old spots	Lists only "Fragrance"	$0.75 per ozas listed	$23.92
Rocco & Roxie Extreme Stain & Odor Eliminator Spray, 32 fl oz3	Bacteria plus mineral odor blocker	Names mattresses	30 to 60 minutes for new stains; 1 hour or more for deep odors	Lists Meyer lemon oil	$0.87 per ozas listed	$27.97
Nature's Miracle Advanced Dog Stain & Odor Eliminator, 32 fl oz4	Enzyme blend	Not named	15 minutes; old spots get a scrub and 24 hours to dry	Lists only "Fragrance"	$0.42 per ozas listed	$13.57
Resolve Urine Destroyer Spray, 32 fl oz5	Hydrogen peroxide; no enzyme named	Not named	Not published	Not published	$0.31 per ozas listed	$9.99
GEODE Mattress Cleaner & Deodorizer, 32 fl oz6	Enzyme-based (listing)	Named on the listing	Not published	Not published	$0.81 per ozas listed	$25.98
Sunny & Honey Oxy Mattress Cleaner and Stain Remover, 32 fl oz7	Oxygen-based (listing)	Named on the listing	Not published	Not published	$0.62 per ozas listed	$19.99

Prices on Amazon, November 2, 2026.⁸

Is it safe to wet a mattress with an enzyme cleaner?

Rocco & Roxie's FAQ says to spray or pour its cleaner on the mattress and leave it to work.⁹ Purple, a mattress maker, says that urine stains may need an enzyme cleaner or hydrogen peroxide.¹⁰ The same page says you shouldn't get a memory foam mattress wet.²

Those two do not fully agree, and no cleaner maker we read gives a mattress-specific amount. If you have doubts, Purple says to check your mattress maker's care instructions and warranty.¹¹

Which cleaners name mattresses on their own page?

Rocco & Roxie does, for both its standard and Extreme cleaners.¹ The Nature's Miracle page we read names carpets, hard floors, furniture and fabrics, but does not name mattresses.⁴ Reckitt's safety sheet for Resolve gives no surfaces.⁵

GEODE and Sunny & Honey are sold as mattress sprays. We could only read their listings, which do not publish ingredients or directions.⁶

How long should it sit on a mattress?

Rocco & Roxie's general directions say to let its cleaner stand at least 1 hour, and longer is better.¹² For the Extreme spray the label says 30 to 60 minutes on new stains.¹³ Nature's Miracle says to let the area dry for 24 hours.¹⁴

Does the Extreme spray list an oil cats react to?

Yes. Its label lists a Meyer lemon oil blend.¹⁵ Pet Poison Helpline lists citrus oil (d-limonene), pine, peppermint, cinnamon, clove, eucalyptus and tea tree oils among those known to poison cats.¹⁶ The standard Rocco & Roxie label says only "Fragrance".¹

Questions people ask

Can I steam clean a mattress after a urine cleaner?

Purple says not to steam clean a memory foam, latex or adjustable mattress, because the heat and water could damage it.¹⁷ Rocco & Roxie also says not to use its cleaner in a steam cleaner.¹⁸

Does the mattress warranty matter?

Purple says to refer to your mattress maker's care instructions and warranty if you have any doubts.¹¹

Is Angry Orange OK on a mattress?

Angry Orange Enzyme Stain Removers were recalled on January 22, 2026.¹⁹ See the Angry Orange recall page.