Home / Pet stains and odor / Nature's Miracle vs Rocco & Roxie
Nature's Miracle vs Rocco & Roxie: which is better for pet urine
Buy Rocco & Roxie for old or deep pet urine; its maker says to leave it on for 1 hour or longer.1 Buy Nature's Miracle if price per ounce matters most; it says 15 minutes, and its Urine Destroyer Plus lists d-limonene.2
Cheapest per oz: Nature's Miracle Dog Urine Destroyer Plus, 1 gallon, about 25 cents.
Check price on Amazon
Three suspects. One pick.
Rocco & Roxie Stain & Odor Eliminator, 1 gallon
Our pickBetter for old or deep urine. The maker says to leave it on for 1 hour or longer, and it states a Carpet and Rug Institute seal.1
Nature's Miracle Dog Urine Destroyer Plus, 1 gallon
Better on price per ounce. The maker says to soak, wait 15 minutes and blot.2
Watch for: The label lists d-limonene, a citrus oil on Pet Poison Helpline's cat list.
Nature's Miracle Advanced Dog Stain & Odor Eliminator, 32 fl oz
Nature's Miracle, label lists only "Fragrance". The label lists only "Fresh Fragrance", so we can't tell which oils, and the maker adds a scrub step for old stains.3
Nature's Miracle and Rocco & Roxie, side by side
Both sell bacteria-based enzyme sprays. The label and directions differ on wait time, oils and seals.4
| Product | Type | How long it sits | Oils cats react to | Wood | Carpet seal | Cost per oz (ready to use) | Price |
|---|---|---|---|---|---|---|---|
| Rocco & Roxie Stain & Odor Eliminator, 1 gallon1 | Bacteria and enzymes | 1 hour or more; up to days for old spots | Lists only "Fragrance" | Light use on wood | CRI Seal on maker page | $0.47 per ozas listed | $59.97 |
| Nature's Miracle Dog Urine Destroyer Plus, 1 gallon2 | Bacteria-made enzymes | 15 minutes | Lists d-limonene (citrus oil) | Not on untreated wood | No CRI Seal on maker page | $0.25 per ozas listed | $31.67 |
| Nature's Miracle Advanced Dog Stain & Odor Eliminator, 32 fl oz3 | Enzyme blend | 15 minutes; old spots get a scrub and 24 hours to dry | Lists only "Fragrance" | Not on untreated wood | No CRI Seal on maker page | $0.42 per ozas listed | $13.57 |
 Rocco & Roxie Extreme Stain & Odor Eliminator Spray, 32 fl oz5 | Bacteria plus mineral odor blocker | 30 to 60 minutes for new stains; 1 hour or more for deep odors | Lists Meyer lemon oil | Light use on wood | CRI Seal on maker page | $0.87 per ozas listed | $27.97 |
Prices on Amazon, November 2, 2026.6
How long does each one sit?
Rocco & Roxie says to let the standard cleaner stand at least 1 hour, and longer is better.4 For stains that are set in, dried up or very deep it says several hours or overnight.7 For older stains its FAQ says a couple of days.8
Nature's Miracle says to soak the spot, wait 15 minutes and blot.2 For old or stubborn odors its Advanced formula says to lay a wet towel over the spot for 1 to 2 hours.9
What is in each one?
Rocco & Roxie's label lists water, an advanced biological blend, a non-ionic surfactant and fragrance.1 The maker says it uses both bacteria and enzymes.10
Nature's Miracle Urine Destroyer Plus lists a microbial mixture, alcohol ethoxylates, a preservative, fragrance and d-limonene.2 Its Advanced cleaner lists an enzymatic blend, isopropyl alcohol, fresh fragrance and a preservative.3
Rocco & Roxie's Extreme spray is different: it lists a Meyer lemon oil blend.11 Pet Poison Helpline lists citrus oil (d-limonene), pine, peppermint, cinnamon, clove, eucalyptus and tea tree oils among those known to poison cats.12
Which one is better on hardwood?
Neither is a clear win. Rocco & Roxie says to use it sparingly on wood, because too much water can swell or warp it.13 Nature's Miracle says not to use its cleaners on untreated hardwood.14 Our hardwood floor page covers this in full.
Which one costs less per ounce?
The table works out cost per ounce from today's price for each bottle. Both makers sell a 1 gallon bottle, which is the larger size for each, so compare the two gallon rows: Nature's Miracle Dog Urine Destroyer Plus2 and Rocco & Roxie Stain & Odor Eliminator.1 Nature's Miracle is the pick when price per ounce matters most.
Questions people ask
Do both use enzymes?
Rocco & Roxie says its formula uses both bacteria and enzymes.10 Nature's Miracle says its bacteria-based formula produces enzymes when it meets a food source like pet urine.2
Can I put either one in a steam cleaner?
Rocco & Roxie says not to, because the heat can deactivate the biological ingredients.15 Nature's Miracle says to use its Advanced cleaner full strength and not dilute it.16
Does either have a carpet seal?
Rocco & Roxie's page says its cleaner earned the Carpet and Rug Institute Seal of Approval.17 We found no seal claim on the Nature's Miracle pages we read.2
If a pet swallows a cleaner, call your vet or the ASPCA Animal Poison Control Center at (888) 426-4435.18
Sources (18)
- Rocco & Roxie Stain & Odor Eliminator, maker page, read November 2, 2026. Quote: “Water, Advanced Biological Blend, Non-Ionic Surfactant, Fragrance.”
- Nature's Miracle Urine Destroyer Plus for Dogs, maker page, read November 2, 2026. Quote: “Water, Alcohol, C9-1, Ethoxylated, Microbial Mixture, Preservative, Fragrance, PolyethyleneGtcol, Pentasodium Triphosphate, Sulphonic Acids, Undecyl Alcohol…”
- Nature's Miracle Advanced Stain and Odor Eliminator, maker page, read November 2, 2026. Quote: “Water, Surfactants, Isopropyl Alcohol, Enzymatic Blend, Fresh Fragrance, Preservative, Odor Counteractant”
- Rocco & Roxie Stain & Odor Eliminator, directions, read November 2, 2026. Quote: “Allow to stand at least 1 hour (longer is better).”
- Rocco & Roxie Extreme Stain & Odor Eliminator, maker page, read November 2, 2026. Quote: “Purified Water, Bacterial Blend, c9-11 Ethoxylated Alcohol, Mineral-Based Odor Counteractant Blend, Natural Meyer Lemon Oil Fragrance Blend”
- Prices and photos: Amazon product data, read November 2, 2026.
- Rocco & Roxie tips and instructions, read November 2, 2026. Quote: “For stains that are set in, dried up, or very deep - you may let our product sit for several hours or, in some cases, overnight.”
- Rocco & Roxie FAQ, read November 2, 2026. Quote: “For older stains, spray on the product and let it sit for a couple of days to get down deep and break down the urine.”
- Nature's Miracle Advanced Stain and Odor Eliminator, directions, read November 2, 2026. Quote: “For severe, old or stubborn odors on carpeting or fabrics, saturate a towel with water and lay over the treated area, letting sit for 1 to 2 hours.”
- Rocco & Roxie tips and instructions, read November 2, 2026. Quote: “Rocco & Roxie 3-in-1 formula uses both bacteria and enzymes.”
- Rocco & Roxie Extreme Stain & Odor Eliminator, label, read November 2, 2026. Quote: “Natural Meyer Lemon Oil Fragrance Blend”
- Pet Poison Helpline: Essential Oils and Cats, read November 2, 2026. Quote: “Essential oils that are known to cause poisoning in cats include oil of wintergreen, oil of sweet birch, citrus oil (d-limonene), pine oils, Ylang Ylang oil…”
- Rocco & Roxie: how to use on hardwood floors, read November 2, 2026. Quote: “Water, when applied excessively, can cause swelling and (in extreme cases) warping in wood.”
- Nature's Miracle Urine Destroyer Plus for Dogs, directions, read November 2, 2026. Quote: “Do not use on untreated hardwood, leather, suede, silk or wool specialty fabrics”
- Rocco & Roxie FAQ: steam cleaners, read November 2, 2026. Quote: “We don't recommend using our product in a steam cleaner, as the high heat can deactivate the biological ingredients, making it ineffective.”
- Nature's Miracle Advanced Stain and Odor Eliminator, directions, read November 2, 2026. Quote: “Always use this product full strength. Do not dilute.”
- Rocco & Roxie Stain & Odor Eliminator, maker page, read November 2, 2026. Quote: “earning the Seal of Approval by the trusted Carpet and Rug Institute (CRI)”
- ASPCA Animal Poison Control, read November 2, 2026. Quote: “If you think your pet may have ingested a potentially poisonous substance, call (888) 426-4435”
The paper trail
Every product on this page was looked up in the EPA Safer Choice list, CPSC recalls, California Prop 65 notices and EWG’s database. We read each maker’s full ingredient label and worked out what a load or an ounce really costs. Every flag links to where it came from. How we snoop.